The 11-Deoxycortisol test measures the levels of 1...

The 11-Deoxycortisol test measures the levels of 11-Deoxycortisol in the blood. This test is used to diagnose and monitor patients with congenital adrenal hyperplasia due to 11-hydroxylase deficiency, as well as assess adrenal response to metyrapone in cases of Cushing's syndrome. It helps identify abnormalities in the adrenal gland and the 11-hydroxylase enzyme, which is crucial for cortisol production. Purpose and Significance: Diagnosis and Monitoring: The 11-Deoxycortisol test is a valuable tool for diagnosing congenital adrenal hyperplasia (CAH) caused by a deficiency in the 11β-hydroxylase enzyme. This enzyme is responsible for converting 11-Deoxycortisol into cortisol, a stress hormone. Metyrapone Testing: The test is also used in the metyrapone test, which helps assess the adrenal response to metyrapone, a drug that inhibits 11-hydroxylase activity. This test is crucial in differentiating between different causes of Cushing's syndrome. Adrenal Function: By measuring 11-Deoxycortisol levels, doctors can assess the function of the adrenal glands and identify any potential imbalances in the production of cortisol and other adrenal hormones. How it Works: The 11-Deoxycortisol test measures the levels of 11-Deoxycortisol in the blood. 11-Deoxycortisol is a precursor to cortisol, and its levels are affected by the activity of the 11β-hydroxylase enzyme. Elevated levels of 11-Deoxycortisol can indicate a deficiency in this enzyme, which can lead to CAH. The test is often used in conjunction with other tests, such as the Metyrapone test, to provide a comprehensive assessment of adrenal function. Clinical Applications: Congenital Adrenal Hyperplasia (CAH): Specifically, CAH due to 11β-hydroxylase deficiency. Metyrapone Testing: To assess adrenal response to metyrapone in patients with Cushing's syndrome. Differential Diagnosis of Cushing's Syndrome: To help determine the underlying cause of Cushing's syndrome. Turnaround Time: The 11-Deoxycortisol test results are typically available within 36 hours of the blood sample collection. Turnaround times can vary depending on the laboratory and the test method used. Note: This information is for general knowledge and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.