Sex Hormone-Binding Globulin (SHBG) is a liver-produced protein that transports sex hormones (like testosterone and estrogen) in the blood, controlling how much is "free" and active in the body. Measuring SHBG levels helps diagnose hormone imbalances, with high levels sometimes seen in hyperthyroidism or liver issues, and low levels linked to metabolic syndrome, PCOS, and insulin resistance. Its levels are influenced by hormones, thyroid function, insulin, diet, and certain medications, making it a key biomarker for reproductive and metabolic health.
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