A serum erythropoietin (EPO) test is a blood test that measures levels of the hormone EPO, primarily made by the kidneys, which tells the bone marrow to produce red blood cells (RBCs) for oxygen transport; it helps diagnose anemia, polycythemia, or kidney issues by revealing if EPO is too high, too low, or normal, guiding treatment for RBC production disorders or kidney disease. The simple blood draw requires no special prep, and results help determine if low RBCs are due to a kidney problem (high EPO) or bone marrow issue (low EPO).
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