Acanthocyte tests primarily use a Peripheral Blood Smear (PBS) to identify red blood cells (RBCs) with irregular, spiky projections, alongside a CBC for anemia and other blood markers, and specific tests (like lipid panels, liver function, or genetics) to find the underlying cause, which can range from liver disease (spur cells) to rare disorders like neuroacanthocytosis or abetalipoproteinemia, indicating altered RBC membrane lipids/proteins.
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