A 20q deletion, or del(20q), refers to the loss of a portion of the long arm (q arm) of chromosome 20. This genetic alteration is commonly observed in myeloid neoplasms, including myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN). It can also be associated with other conditions like therapy-related myeloid neoplasms.