17 oh progesterone 17-Hydroxyprogesterone (17-OHP) is a steroid hormone produced by the adrenal glands, primarily during the synthesis of cortisol. A 17-OHP test measures the amount of 17-OHP in the blood and is mainly used to screen newborns for Congenital Adrenal Hyperplasia (CAH), a genetic disorder. It can also be used to monitor CAH treatment and investigate infertility in men. Here's a more detailed explanation: What it is: 17-OHP is a steroid hormone produced by the adrenal glands, which are located on top of the kidneys. What it's used for: Newborn Screening: The 17-OHP test is a routine newborn screening test in many places to detect CAH. Monitoring CAH Treatment: The test is used to monitor the effectiveness of treatment for CAH. Investigating Infertility: It can be used to investigate infertility in men. Evaluation of Adrenal or Ovarian Tumors: In some cases, it can help evaluate adrenal or ovarian tumors, although other tests are typically needed for confirmation. Why it's important: CAH: CAH is a genetic disorder that affects the adrenal glands' ability to produce cortisol, leading to potential health problems like ambiguous genitalia in newborns. Cortisol Production: 17-OHP is a precursor in the synthesis of cortisol, a hormone that plays a crucial role in regulating blood pressure, blood sugar, and the body's response to stress. How it's tested: A blood sample is taken, typically from a vein in the arm or, in newborns, a heel prick. What to expect: The test results will indicate the level of 17-OHP in the blood, which can help diagnose CAH or other conditions.